KAJIAN KUALITAS PENGGUNAAN ANTIBIOTIK MEROPENEM SEBELUM DAN SESUDAH PEMBERIAN INFORMASI OBAT DI BANGSAL RAWAT INAP RSUD KABUPATEN JOMBANG
Meropenem is a broad-spectrum and most expensive antimicrobial agent that highly potent as empirical and definitive therapy against serious infection caused by multi-drug resistant organism (MDRO). But meropenem use is now threatened by the emerging of several reports about resistance to this agent....
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| Main Authors: | , |
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| Format: | Theses and Dissertations NonPeerReviewed |
| Published: |
[Yogyakarta] : Universitas Gadjah Mada
2013
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| Subjects: | |
| Online Access: | https://repository.ugm.ac.id/123109/ http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=63220 |
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| Institution: | Universitas Gadjah Mada |
| Summary: | Meropenem is a broad-spectrum and most expensive antimicrobial agent that
highly potent as empirical and definitive therapy against serious infection caused
by multi-drug resistant organism (MDRO). But meropenem use is now threatened
by the emerging of several reports about resistance to this agent. The antibiotic
resistance may emerge as a result of inappropriate use of antibiotic. Hospital
pharmacist has the role and responsibility to improve drug use appropriateness.
This study will assess the quality (appropriateness) use of meropenem in regional
general hospital of Kabupaten Jombang using Gyssens� category flowchart.
This study conducted into two-phase quality evaluation, 3-month in
retrospective during October-December 2012 and 3-month in prospective during
February-April 2013. Provision of drug information to prescribers as a discusssion
using leaflet contains meropenem information was given by researcher in the
intervening period.
The qualitative evaluation of meropenem use in regional general hospital
inpatient wards of Kabupaten Jombang had results that the appropriateness use of
meropenem increase after drug information provision from 7,1% to 39,4%
(p<0,05). Provision of drug information decrease inappropriate use of meropenem
due to inappropriate dose (from 32,1% to 30,3%), inappropriate administration
interval (from 50,0% to 27,3%), duration too long (from 35,71% to 6,1%) and the
availability of more cheapest and narrower-spectrum alternative agents (from
64,3% to 48,5%). |
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