STUDY OF QUINOLONE CLASS ANTIBIOTICS SENSITIVITY TESTING ON ESBL (EXTENDED SPECTRUM β-LACTAMASE) PRODUCING PSEUDOMONAS AERUGINOSA IN CLINICAL ISOLATES FROM YOGYAKARTA
Background: Pseudomonas aeruginosa is an important pathogen commonly implicated in serious nosocomial infections such as pneumonia and sepsis lung infections and death in children and adults with cystic fibrosis. It is known to exhibit intrinsic resistance to several antimicrobial agents. In additio...
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| Main Authors: | , |
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| Format: | Theses and Dissertations NonPeerReviewed |
| Published: |
[Yogyakarta] : Universitas Gadjah Mada
2013
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| Subjects: | |
| Online Access: | https://repository.ugm.ac.id/123224/ http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=63335 |
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| Institution: | Universitas Gadjah Mada |
| Summary: | Background: Pseudomonas aeruginosa is an important
pathogen commonly implicated in serious nosocomial
infections such as pneumonia and sepsis lung infections
and death in children and adults with cystic fibrosis.
It is known to exhibit intrinsic resistance to several
antimicrobial agents. In addition to the intrinsic
resistance of P. aeruginosa, it also produces the
enzymes, namely �-lactamases, which are responsible for
the wide spread �-lactam resistance.
Objective: The objective of this study is to know the
sensitivity of the Quinolone class antibiotics towards
ESBL producing Pseudomonas aeruginosa.
Method: This descriptive study was carried out on 30
isolates of P. aeruginosa obtained from several
hospitals in Yogyakarta. ESBL producing isolates were
screened with ESBL detection test and confirmed with
phenotypic ESBL confirmatory test. Antibiotic
susceptibility test were done by Kirby Bauer method and
interpreted according to CLSI guideline for four
quinolone class antibiotics.
Result: Among the 30 isolates of P. aeruginosa obtained
it was found that 22 (73.33%) of them are ESBLproducers.
The ESBL producing P. aeruginosa isolates
were found to be highly susceptible to Norfloxacin
(86%) followed by Ciprofloxacin and Ofloxacin (77%) and
the last levofloxacin (73%).
Conclusion: Prevalence of P. aeruginosa producing ESBL
in Yogyakarta is quite high in the isolates obtained
and they are highly susceptible to Norfloxacin. |
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