EFEK APLIKASI GEL EKSTRAK KULIT MANGGIS (Garcinia mangostana L.) TERHADAP KEPADATAN SERABUT KOLAGEN PADA PROSES PENYEMBUHAN LUKA GINGIVA (KAJIAN PADA Rattus norvegicus)
Mangosteen peel (Garcinia mangostana L.) is believed as a mature fruit with many special advantages to a wide range of pharmacological activities, one of which is for healing wounds. The mangosteen peel contained several important substances that can act as anti-inflammatory agents, such as γ-mango...
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| Main Authors: | , |
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| Format: | Theses and Dissertations NonPeerReviewed |
| Published: |
[Yogyakarta] : Universitas Gadjah Mada
2013
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| Subjects: | |
| Online Access: | https://repository.ugm.ac.id/123601/ http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=63714 |
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| Institution: | Universitas Gadjah Mada |
| Summary: | Mangosteen peel (Garcinia mangostana L.) is believed as a mature fruit
with many special advantages to a wide range of pharmacological activities, one
of which is for healing wounds. The mangosteen peel contained several important
substances that can act as anti-inflammatory agents, such as γ-mangostin and
flavonoids. Because of this potential, this study aimed to determine the effect of
mangosteen peel extract gel application (Garcinia mangostana L.) against the
density of collagen fibers in the gingival wound healing (studies on Rattus
norvegicus).
The study sample consisted of 27 Rattus norvegicus rats in 3 months old
with body weight of 200-250 grams, which given a wound by punch biopsy on its
mandibular labial gingiva. The samples were divided into 3 groups, the positive
control group (using aloclair gel), treatment group (using the mangosteen peel
extract gel), and the negative control group (using a 2% CMC-Na gel). Samples
were then decapitated, 3 mice from each group on days 3, 7, and 14. From wound
tissue, it was made into histological specimens which later stained with Trichrome
Mallory to assess the density of collagen fibers. The data obtained were tested
with Kruskal-Wallis and Mann-Whitney U tests.
The results showed that there was no significant difference in the density
of collagen fibers between the positive control group and the treatment group (p �
0.05) on days 3, 7, 14, and there were significant differences between the
treatment group and the negative control group on day -7 (p <0,05). Through the
results of this study, it can be seen that mangosteen peel extract gel (Garcinia
mangostana L.) is able to accelerate the density of collagen fibers in the gingival
wound healing (studies on Rattus norvegicus) which particularly shown on day-7
observations |
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