HUBUNGAN ANTARA FRAGMENTASI DNA SPERMA DAN MOTILITAS SPERMA PADA KASUS INFERTILITAS PRIA
Background: It is estimated there are 10-15% cases of infertility among couples worldwide, and half of the cause lies in men. Routine sperm analysis by WHO is not sufficient to assess male fertility and not always capable to explain the cause of infertility in men. Sperm motility is a clinical indic...
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| Main Authors: | , |
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| Format: | Theses and Dissertations NonPeerReviewed |
| Published: |
[Yogyakarta] : Universitas Gadjah Mada
2014
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| Subjects: | |
| Online Access: | https://repository.ugm.ac.id/128412/ http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=68757 |
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| Institution: | Universitas Gadjah Mada |
| Summary: | Background: It is estimated there are 10-15% cases of
infertility among couples worldwide, and half of the cause
lies in men. Routine sperm analysis by WHO is not sufficient
to assess male fertility and not always capable to explain
the cause of infertility in men. Sperm motility is a
clinical indicator of sperm quality and fertilization
potential. Sperm DNA integrity test
is required to assess the fertility status. However, the
relationship between them is not clear yet.
Objective: This study evaluated the relationship between
sperm DNA fragmentation and sperm motility in male
infertility cases.
Methods: The study was performed using analytical
observational with cross-sectional method. Subjects were 28
men following In Vitro Fertilization (IVF) program. Routin
sperm analysis had been performed initially and continued
with DNA fragmentation testing in Permata Hati clinical
laboratory, RSUP Dr.Sardjito Yogyakarta.
Results: There was a significant relationship between sperm
DNA fragmentation and sperm motility (p=0,03). Logistic
regression analysis showed both statistically and clinically
significant association between DNA fragmentation and sperm
motility (OR 6.67 |
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