HUBUNGAN ANTARA FRAGMENTASI DNA SPERMA DAN MOTILITAS SPERMA PADA KASUS INFERTILITAS PRIA

• Main Authors: , NAERA NOVIDA A, , Prof. dr. Djaswadi Dasuki, Sp.OG., MPH., Ph.D.
• Format: Theses and Dissertations NonPeerReviewed
• Published: [Yogyakarta] : Universitas Gadjah Mada 2014
• Subjects: ETD
• Online Access: https://repository.ugm.ac.id/128412/; http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=68757
• Institution: Universitas Gadjah Mada

Background: It is estimated there are 10-15% cases of infertility among couples worldwide, and half of the cause lies in men. Routine sperm analysis by WHO is not sufficient to assess male fertility and not always capable to explain the cause of infertility in men. Sperm motility is a clinical indicator of sperm quality and fertilization potential. Sperm DNA integrity test is required to assess the fertility status. However, the relationship between them is not clear yet. Objective: This study evaluated the relationship between sperm DNA fragmentation and sperm motility in male infertility cases. Methods: The study was performed using analytical observational with cross-sectional method. Subjects were 28 men following In Vitro Fertilization (IVF) program. Routin sperm analysis had been performed initially and continued with DNA fragmentation testing in Permata Hati clinical laboratory, RSUP Dr.Sardjito Yogyakarta. Results: There was a significant relationship between sperm DNA fragmentation and sperm motility (p=0,03). Logistic regression analysis showed both statistically and clinically significant association between DNA fragmentation and sperm motility (OR 6.67