PENGARUH PEMBERIAN EKSTRAK ETANOL BENALU TEH (Scurrula atropurpurea) TERHADAP AKTIVITAS FAGOSITOSIS MAKROFAG PERITONEAL MENCIT (Mus musculus) GALUR BALB-C YANG DIINFEKSI Staphylococcus aureus

• Main Authors: , MUHAMMAD FAISHAL ULIL ALBAB, , Prof. Dr. drh. Siti Isrina Oktavia Salasiaselaku
• Format: Theses and Dissertations NonPeerReviewed
• Published: [Yogyakarta] : Universitas Gadjah Mada 2014
• Subjects: ETD
• Online Access: https://repository.ugm.ac.id/130142/; http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=70557
• Institution: Universitas Gadjah Mada

The present study aimed to determine the effect of administration of the ethanol effect oftea parasite herb (Scurrula atropurpurea) againstphagocytic macrophage cells of mice infected withstaphylococcus aureus. In the present study, wereused 15 four-weeks-old mice with the average weight of 20 grams, which were then divided in to 3 different groupswas consisted of 5 mice. Group I (KI) was the control group, where each everymice was infected with 1 x 102Staphylococcus aureus /mLintraperitoneally (IP) at the first day, then the mice wasgiven 0,05 mL phosphat buffer saline (PBS) per oral (PO). Group II (KII), each mice was infected by Staphylococcus aureusat the first day, then the mice wasgiven the extract of tea parasite herb daily with the dose of 0.12 grams/20 grams body weight for a week. Group III (KIII) each mouse was infected by Staphylococcus aureusat the first day, then was given the extract of Tea parasite herb daily with the dose of 0.24 grams/ 20 grams of body weight for aweek. At the end of the study, mice were euthanized and prepared for peritoneal macrophages. Isolation theperitoneal macrophages were used forbacterial phagocyticassay in vitro. The result showed that the tea parasite herb�s extract which was given daily with dose of 0.12 grams/ 20 gram body weight (KII) could enhance the ability of macrophage cells to phagocyte the bacteria(10.7±2.958 bacteria/macrophage), thedose of 0.24 grams/20 grams (KIII)(12.75±4.375 bacteria/macrophage)and in compared to the control goup (KI) (10.1±3.463bacteria/macrophage)(P > 0.05). Keywords:Staphylococcus aureus, tea parasite herb (Scurrula atropurpurea),macrophage