GAMBARAN HISTOPALOGI LIMPA TIKUS Sprague Dawley AKIBAT PAPARAN KRONIS 1,2- Dimethylhydrazine

• Main Authors: , REZEKI MULIANI, , drh. Sitarina Widyarini, MP., Ph.D.
• Format: Theses and Dissertations NonPeerReviewed
• Published: [Yogyakarta] : Universitas Gadjah Mada 2014
• Subjects: ETD
• Online Access: https://repository.ugm.ac.id/130875/; http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=71308
• Institution: Universitas Gadjah Mada

The aim of this study was to identify histopathology Sprague Dawley rat spleen induced subcutaneous with 1.2 Dimethylhydrazine. This study was conducted in the Laboratory of Pathology, Faculty of Veterinary Medicine, Gadjah Mada University, Yogyakarta . Ten rats with age 1.5 month old were divided into 2 groups . Group I as much as 5 rats as control given Carboxy Methyl Cellulose ( CMC ) with a concentration 0.1 % in oral, group II as many as 10 rats treated subcutaneously induced with 1,2 Dimethylhydrazine ( DMH ) at a dose of 60 mg / kg BB for 15 weeks . At week 15, mice euthanasia using chloroform , then spleen should be taken and put inside in 10 % formalin and made into histological preparations . The data was analyzed descriptive by comparing the changes in the control and treatment groups . Based on the results of this study it can be concluded that the DMH may cause the spleen to change with the increase in quality pigment hemosidirin that looks a lot more exposure to DMH that cause oxidative damage to erythrocytes