PENGARUH INFEKSI Mycobacterium tuberculosis TERHADAP SISTEM IMUN DI DALAM PARU-PARU DAN LIMFA

• Main Authors: , SHEILLA YUDIANA, , Dr. Fajar Adi Kusumo, S.Si., M.Si.
• Format: Theses and Dissertations NonPeerReviewed
• Published: [Yogyakarta] : Universitas Gadjah Mada 2014
• Subjects: ETD
• Online Access: https://repository.ugm.ac.id/131515/; http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=72011
• Institution: Universitas Gadjah Mada

Tuberculosis is one of the diseases which caused the highest mortality in developing countries. This disease is caused by an agent called Mycobacterium tuberculosis. The main targets of the agent are macrophages and important immune system cells. A better understanding of the interaction between Mycobacterium tuberculosis and immune system will contribute to the design of mathematical model to control tuberculosis. The model is used to understand the effect of Mycobacterium tuberculosis infection to the immune system in lung. Furthermore, the model is expanded by adding up dendritic cell population as the immune system to control Mycobacterium tuberculosis infection in lung and lymph. Model analysis reveals existence of two equilibrium states, infection free equilibrium and the endemically infected equilibrium. The equilibriums represent a state of latent or active infection, depending on the amount of bacteria.