Pengaruh polimorfisme C677T gena methylentetrahydrofolate reductase (MTHFR) terhadap kejadian relaps pada anak dengan Leukemia limfoblastik akut (LLA)

Methotrexate is a key drug in acute lymphoblastic leukemia (ALL) treatment. It inhibits DNA replication by blocking the conversion of 5,10 methylenetetrahydrofolate to 5-methylenetetrahydrofolate by methylene tetrahydrofolate reductase, a critical enzyme involved in folate metabolism, DNA methylatio...

Full description

Saved in:

Bibliographic Details
Main Authors:	, DENNY WELLYAM SIGARLAKI, , Dr. dr. Sri Mulatsih, SpAK
Format:	Theses and Dissertations NonPeerReviewed
Published:	[Yogyakarta] : Universitas Gadjah Mada 2014
Subjects:	ETD
Online Access:	https://repository.ugm.ac.id/133243/ http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=73807
Tags:	Add Tag No Tags, Be the first to tag this record!
Institution:	Universitas Gadjah Mada

id	id-ugm-repo.133243
record_format	dspace
spelling	id-ugm-repo.1332432016-03-04T07:54:26Z https://repository.ugm.ac.id/133243/ Pengaruh polimorfisme C677T gena methylentetrahydrofolate reductase (MTHFR) terhadap kejadian relaps pada anak dengan Leukemia limfoblastik akut (LLA) , DENNY WELLYAM SIGARLAKI , Dr. dr. Sri Mulatsih, SpAK ETD Methotrexate is a key drug in acute lymphoblastic leukemia (ALL) treatment. It inhibits DNA replication by blocking the conversion of 5,10 methylenetetrahydrofolate to 5-methylenetetrahydrofolate by methylene tetrahydrofolate reductase, a critical enzyme involved in folate metabolism, DNA methylation and synthesis. It has two common functional polymorphism (C677>T and A1298>C). Genetic polymorphisms of this enzyme have been shown to impact relapse risk in childhood ALL. This study aimed to asses the impact of MTHFR polymorphisms C677>T on the relapse of childhood ALL. This case-control study was undertaken to analyze the presence of the C677>T mutant alleles in 36 (relapse group) and 36 (no relapse group) childhood ALL patients. Polymorphisms in MTHFR C677>T were detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The frequency of polymorphism are higher in the control (19% vs 8,8%), but not significantly different (OR 0,379 [Yogyakarta] : Universitas Gadjah Mada 2014 Thesis NonPeerReviewed , DENNY WELLYAM SIGARLAKI and , Dr. dr. Sri Mulatsih, SpAK (2014) Pengaruh polimorfisme C677T gena methylentetrahydrofolate reductase (MTHFR) terhadap kejadian relaps pada anak dengan Leukemia limfoblastik akut (LLA). UNSPECIFIED thesis, UNSPECIFIED. http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=73807
institution	Universitas Gadjah Mada
building	UGM Library
country	Indonesia
collection	Repository Civitas UGM
topic	ETD
spellingShingle	ETD , DENNY WELLYAM SIGARLAKI , Dr. dr. Sri Mulatsih, SpAK Pengaruh polimorfisme C677T gena methylentetrahydrofolate reductase (MTHFR) terhadap kejadian relaps pada anak dengan Leukemia limfoblastik akut (LLA)
description	Methotrexate is a key drug in acute lymphoblastic leukemia (ALL) treatment. It inhibits DNA replication by blocking the conversion of 5,10 methylenetetrahydrofolate to 5-methylenetetrahydrofolate by methylene tetrahydrofolate reductase, a critical enzyme involved in folate metabolism, DNA methylation and synthesis. It has two common functional polymorphism (C677>T and A1298>C). Genetic polymorphisms of this enzyme have been shown to impact relapse risk in childhood ALL. This study aimed to asses the impact of MTHFR polymorphisms C677>T on the relapse of childhood ALL. This case-control study was undertaken to analyze the presence of the C677>T mutant alleles in 36 (relapse group) and 36 (no relapse group) childhood ALL patients. Polymorphisms in MTHFR C677>T were detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The frequency of polymorphism are higher in the control (19% vs 8,8%), but not significantly different (OR 0,379
format	Theses and Dissertations NonPeerReviewed
author	, DENNY WELLYAM SIGARLAKI , Dr. dr. Sri Mulatsih, SpAK
author_facet	, DENNY WELLYAM SIGARLAKI , Dr. dr. Sri Mulatsih, SpAK
author_sort	, DENNY WELLYAM SIGARLAKI
title	Pengaruh polimorfisme C677T gena methylentetrahydrofolate reductase (MTHFR) terhadap kejadian relaps pada anak dengan Leukemia limfoblastik akut (LLA)
title_short	Pengaruh polimorfisme C677T gena methylentetrahydrofolate reductase (MTHFR) terhadap kejadian relaps pada anak dengan Leukemia limfoblastik akut (LLA)
title_full	Pengaruh polimorfisme C677T gena methylentetrahydrofolate reductase (MTHFR) terhadap kejadian relaps pada anak dengan Leukemia limfoblastik akut (LLA)
title_fullStr	Pengaruh polimorfisme C677T gena methylentetrahydrofolate reductase (MTHFR) terhadap kejadian relaps pada anak dengan Leukemia limfoblastik akut (LLA)
title_full_unstemmed	Pengaruh polimorfisme C677T gena methylentetrahydrofolate reductase (MTHFR) terhadap kejadian relaps pada anak dengan Leukemia limfoblastik akut (LLA)
title_sort	pengaruh polimorfisme c677t gena methylentetrahydrofolate reductase (mthfr) terhadap kejadian relaps pada anak dengan leukemia limfoblastik akut (lla)
publisher	[Yogyakarta] : Universitas Gadjah Mada
publishDate	2014
url	https://repository.ugm.ac.id/133243/ http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=73807
_version_	1681233648016162816

Pengaruh polimorfisme C677T gena methylentetrahydrofolate reductase (MTHFR) terhadap kejadian relaps pada anak dengan Leukemia limfoblastik akut (LLA)

Similar Items