Synthesis of new activated indoles
344=Bromopheny1)-4,6-dimethoxy-2-methylindole has been synthesized from 4, 6-dimethoxyaniline via the modified Bischler method. Reaction of 4,6-dimethoxyaniline with 2,4-dibromopropiophenone gave an aniline ketone in 85%, and then it was protected to give the amido ketone as a white solid. Cyclizati...
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| Format: | Article NonPeerReviewed |
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[Yogyakarta] : Universitas Gadjah Mada
2004
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| Online Access: | https://repository.ugm.ac.id/17732/ http://i-lib.ugm.ac.id/jurnal/download.php?dataId=495 |
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| Institution: | Universitas Gadjah Mada |
| Summary: | 344=Bromopheny1)-4,6-dimethoxy-2-methylindole has been synthesized from 4, 6-dimethoxyaniline via the modified Bischler method. Reaction of 4,6-dimethoxyaniline with 2,4-dibromopropiophenone gave an aniline ketone in 85%, and then it was protected to give the amido ketone as a white solid. Cyclization of amido ketone was performed by trifluoroacetic acid and subsequent deprotection with potassium hydroxide in methanol afforded a white solid of 3(4'-bromopheny0-4,6-dimethoxy-2-methylindole in 86%.
Keywords: 4, 6-dimethoxyaniline, 2-methylindole, Bischler method |
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