Synthesis of new activated indoles

344=Bromopheny1)-4,6-dimethoxy-2-methylindole has been synthesized from 4, 6-dimethoxyaniline via the modified Bischler method. Reaction of 4,6-dimethoxyaniline with 2,4-dibromopropiophenone gave an aniline ketone in 85%, and then it was protected to give the amido ketone as a white solid. Cyclizati...

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Main Author:	Perpustakaan UGM, i-lib
Format:	Article NonPeerReviewed
Published:	[Yogyakarta] : Universitas Gadjah Mada 2004
Subjects:	Jurnal i-lib UGM
Online Access:	https://repository.ugm.ac.id/17732/ http://i-lib.ugm.ac.id/jurnal/download.php?dataId=495
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Institution:	Universitas Gadjah Mada

id	id-ugm-repo.17732
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spelling	id-ugm-repo.177322014-06-18T00:29:23Z https://repository.ugm.ac.id/17732/ Synthesis of new activated indoles Perpustakaan UGM, i-lib Jurnal i-lib UGM 344=Bromopheny1)-4,6-dimethoxy-2-methylindole has been synthesized from 4, 6-dimethoxyaniline via the modified Bischler method. Reaction of 4,6-dimethoxyaniline with 2,4-dibromopropiophenone gave an aniline ketone in 85%, and then it was protected to give the amido ketone as a white solid. Cyclization of amido ketone was performed by trifluoroacetic acid and subsequent deprotection with potassium hydroxide in methanol afforded a white solid of 3(4'-bromopheny0-4,6-dimethoxy-2-methylindole in 86%. Keywords: 4, 6-dimethoxyaniline, 2-methylindole, Bischler method [Yogyakarta] : Universitas Gadjah Mada 2004 Article NonPeerReviewed Perpustakaan UGM, i-lib (2004) Synthesis of new activated indoles. Jurnal i-lib UGM. http://i-lib.ugm.ac.id/jurnal/download.php?dataId=495
institution	Universitas Gadjah Mada
building	UGM Library
country	Indonesia
collection	Repository Civitas UGM
topic	Jurnal i-lib UGM
spellingShingle	Jurnal i-lib UGM Perpustakaan UGM, i-lib Synthesis of new activated indoles
description	344=Bromopheny1)-4,6-dimethoxy-2-methylindole has been synthesized from 4, 6-dimethoxyaniline via the modified Bischler method. Reaction of 4,6-dimethoxyaniline with 2,4-dibromopropiophenone gave an aniline ketone in 85%, and then it was protected to give the amido ketone as a white solid. Cyclization of amido ketone was performed by trifluoroacetic acid and subsequent deprotection with potassium hydroxide in methanol afforded a white solid of 3(4'-bromopheny0-4,6-dimethoxy-2-methylindole in 86%. Keywords: 4, 6-dimethoxyaniline, 2-methylindole, Bischler method
format	Article NonPeerReviewed
author	Perpustakaan UGM, i-lib
author_facet	Perpustakaan UGM, i-lib
author_sort	Perpustakaan UGM, i-lib
title	Synthesis of new activated indoles
title_short	Synthesis of new activated indoles
title_full	Synthesis of new activated indoles
title_fullStr	Synthesis of new activated indoles
title_full_unstemmed	Synthesis of new activated indoles
title_sort	synthesis of new activated indoles
publisher	[Yogyakarta] : Universitas Gadjah Mada
publishDate	2004
url	https://repository.ugm.ac.id/17732/ http://i-lib.ugm.ac.id/jurnal/download.php?dataId=495
_version_	1681217135844524032

Synthesis of new activated indoles

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