A Potential Alkaloid Compound Isolated from a marine sponge collection number MD-02 againts cancer
Majority of the currently available anticancer drugs are designed to have selective toxicity to rapidly dividing cells. Among these agents the focus of many studies are compounds obtained from natural products with high therapeutic index. In this study the cytotoxicity of a marine alkaloid compound...
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| Format: | Article NonPeerReviewed |
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[Yogyakarta] : Universitas Gadjah Mada
2004
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| Online Access: | https://repository.ugm.ac.id/18480/ http://i-lib.ugm.ac.id/jurnal/download.php?dataId=1269 |
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| Institution: | Universitas Gadjah Mada |
| Summary: | Majority of the currently available anticancer drugs are designed to have selective toxicity to rapidly dividing cells. Among these agents the focus of many studies are compounds obtained from natural products with high therapeutic index. In this study the cytotoxicity of a marine alkaloid compound isolated from sponges collection number MD-02 on cancer and normal cells was evaluated.
The compound was obtained from chloroform fractions of sponges followed by Vacuum Liquid Chromatography and TLC-preparative. This compound in a concentration dependent manner inhibit the growth of human cancer cells and were more toxic to Raji than HeLa cells with LC, of 6.37 and 22.67 ug/mL, respectively. Cells treated with this compound showed cleavage of chromosomal DNA into fragments, suggesting the possibility of apoptotic cell death. This compound was less toxic to normal Vero cells showing its selectivity with LC� of 100.36 ug/mL.
Key Words: Antitumor agents, sponges, alkaloid, HeLa, Raji, Vero |
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