A Potential Alkaloid Compound Isolated from a marine sponge collection number MD-02 againts cancer

Majority of the currently available anticancer drugs are designed to have selective toxicity to rapidly dividing cells. Among these agents the focus of many studies are compounds obtained from natural products with high therapeutic index. In this study the cytotoxicity of a marine alkaloid compound...

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Main Author:	Perpustakaan UGM, i-lib
Format:	Article NonPeerReviewed
Published:	[Yogyakarta] : Universitas Gadjah Mada 2004
Subjects:	Jurnal i-lib UGM
Online Access:	https://repository.ugm.ac.id/18480/ http://i-lib.ugm.ac.id/jurnal/download.php?dataId=1269
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Institution:	Universitas Gadjah Mada

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spelling	id-ugm-repo.184802014-06-18T00:29:05Z https://repository.ugm.ac.id/18480/ A Potential Alkaloid Compound Isolated from a marine sponge collection number MD-02 againts cancer Perpustakaan UGM, i-lib Jurnal i-lib UGM Majority of the currently available anticancer drugs are designed to have selective toxicity to rapidly dividing cells. Among these agents the focus of many studies are compounds obtained from natural products with high therapeutic index. In this study the cytotoxicity of a marine alkaloid compound isolated from sponges collection number MD-02 on cancer and normal cells was evaluated. The compound was obtained from chloroform fractions of sponges followed by Vacuum Liquid Chromatography and TLC-preparative. This compound in a concentration dependent manner inhibit the growth of human cancer cells and were more toxic to Raji than HeLa cells with LC, of 6.37 and 22.67 ug/mL, respectively. Cells treated with this compound showed cleavage of chromosomal DNA into fragments, suggesting the possibility of apoptotic cell death. This compound was less toxic to normal Vero cells showing its selectivity with LCâ�� of 100.36 ug/mL. Key Words: Antitumor agents, sponges, alkaloid, HeLa, Raji, Vero [Yogyakarta] : Universitas Gadjah Mada 2004 Article NonPeerReviewed Perpustakaan UGM, i-lib (2004) A Potential Alkaloid Compound Isolated from a marine sponge collection number MD-02 againts cancer. Jurnal i-lib UGM. http://i-lib.ugm.ac.id/jurnal/download.php?dataId=1269
institution	Universitas Gadjah Mada
building	UGM Library
country	Indonesia
collection	Repository Civitas UGM
topic	Jurnal i-lib UGM
spellingShingle	Jurnal i-lib UGM Perpustakaan UGM, i-lib A Potential Alkaloid Compound Isolated from a marine sponge collection number MD-02 againts cancer
description	Majority of the currently available anticancer drugs are designed to have selective toxicity to rapidly dividing cells. Among these agents the focus of many studies are compounds obtained from natural products with high therapeutic index. In this study the cytotoxicity of a marine alkaloid compound isolated from sponges collection number MD-02 on cancer and normal cells was evaluated. The compound was obtained from chloroform fractions of sponges followed by Vacuum Liquid Chromatography and TLC-preparative. This compound in a concentration dependent manner inhibit the growth of human cancer cells and were more toxic to Raji than HeLa cells with LC, of 6.37 and 22.67 ug/mL, respectively. Cells treated with this compound showed cleavage of chromosomal DNA into fragments, suggesting the possibility of apoptotic cell death. This compound was less toxic to normal Vero cells showing its selectivity with LCâ�� of 100.36 ug/mL. Key Words: Antitumor agents, sponges, alkaloid, HeLa, Raji, Vero
format	Article NonPeerReviewed
author	Perpustakaan UGM, i-lib
author_facet	Perpustakaan UGM, i-lib
author_sort	Perpustakaan UGM, i-lib
title	A Potential Alkaloid Compound Isolated from a marine sponge collection number MD-02 againts cancer
title_short	A Potential Alkaloid Compound Isolated from a marine sponge collection number MD-02 againts cancer
title_full	A Potential Alkaloid Compound Isolated from a marine sponge collection number MD-02 againts cancer
title_fullStr	A Potential Alkaloid Compound Isolated from a marine sponge collection number MD-02 againts cancer
title_full_unstemmed	A Potential Alkaloid Compound Isolated from a marine sponge collection number MD-02 againts cancer
title_sort	potential alkaloid compound isolated from a marine sponge collection number md-02 againts cancer
publisher	[Yogyakarta] : Universitas Gadjah Mada
publishDate	2004
url	https://repository.ugm.ac.id/18480/ http://i-lib.ugm.ac.id/jurnal/download.php?dataId=1269
_version_	1681217277872046080

A Potential Alkaloid Compound Isolated from a marine sponge collection number MD-02 againts cancer

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