SYNTHESIS AND BIOLOGICAL ACTIVITY OF SOME 4-SUBSTITUTED CURCUM1N DERIVATIVES

ABSTRACT: A series of 4-substituted curcumin (14 compounds : seven aryl substituted, six alkyl subsituted and curcumin) have been synthesized. These compounds have been identified and physico-chemically characterized and subsequently they were investigated for their anti-inflammatory activity, stabi...

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Main Author:	Perpustakaan UGM, i-lib
Format:	Article NonPeerReviewed
Published:	[Yogyakarta] : Universitas Gadjah Mada 2000
Subjects:	Jurnal i-lib UGM
Online Access:	https://repository.ugm.ac.id/23019/ http://i-lib.ugm.ac.id/jurnal/download.php?dataId=5947
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Institution:	Universitas Gadjah Mada

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spelling	id-ugm-repo.230192014-06-18T00:34:32Z https://repository.ugm.ac.id/23019/ SYNTHESIS AND BIOLOGICAL ACTIVITY OF SOME 4-SUBSTITUTED CURCUM1N DERIVATIVES Perpustakaan UGM, i-lib Jurnal i-lib UGM ABSTRACT: A series of 4-substituted curcumin (14 compounds : seven aryl substituted, six alkyl subsituted and curcumin) have been synthesized. These compounds have been identified and physico-chemically characterized and subsequently they were investigated for their anti-inflammatory activity, stability in. phosphate buffer, oxygen radical scavenging and inhibitory of cyclooxygenase activities. The synthesis was carried out according to Pabon (1964), following a sequence in accordance with the Topliss scheme. The structure elucidation of all compounds is based on UV-Vis (X Me0H), nuclear magnetic resonance (5 ppm, CDC13 or DMSO-d6) and mass spectra (El, m/z). The anti-inflammatory activity was studied through the inhibition of oedema induced in rat feet by injection of carrageenin according to Winter et al.(1962). Their stability in aqueous solution was observed in phosphate buffer with pH 6.5 [Yogyakarta] : Universitas Gadjah Mada 2000 Article NonPeerReviewed Perpustakaan UGM, i-lib (2000) SYNTHESIS AND BIOLOGICAL ACTIVITY OF SOME 4-SUBSTITUTED CURCUM1N DERIVATIVES. Jurnal i-lib UGM. http://i-lib.ugm.ac.id/jurnal/download.php?dataId=5947
institution	Universitas Gadjah Mada
building	UGM Library
country	Indonesia
collection	Repository Civitas UGM
topic	Jurnal i-lib UGM
spellingShingle	Jurnal i-lib UGM Perpustakaan UGM, i-lib SYNTHESIS AND BIOLOGICAL ACTIVITY OF SOME 4-SUBSTITUTED CURCUM1N DERIVATIVES
description	ABSTRACT: A series of 4-substituted curcumin (14 compounds : seven aryl substituted, six alkyl subsituted and curcumin) have been synthesized. These compounds have been identified and physico-chemically characterized and subsequently they were investigated for their anti-inflammatory activity, stability in. phosphate buffer, oxygen radical scavenging and inhibitory of cyclooxygenase activities. The synthesis was carried out according to Pabon (1964), following a sequence in accordance with the Topliss scheme. The structure elucidation of all compounds is based on UV-Vis (X Me0H), nuclear magnetic resonance (5 ppm, CDC13 or DMSO-d6) and mass spectra (El, m/z). The anti-inflammatory activity was studied through the inhibition of oedema induced in rat feet by injection of carrageenin according to Winter et al.(1962). Their stability in aqueous solution was observed in phosphate buffer with pH 6.5
format	Article NonPeerReviewed
author	Perpustakaan UGM, i-lib
author_facet	Perpustakaan UGM, i-lib
author_sort	Perpustakaan UGM, i-lib
title	SYNTHESIS AND BIOLOGICAL ACTIVITY OF SOME 4-SUBSTITUTED CURCUM1N DERIVATIVES
title_short	SYNTHESIS AND BIOLOGICAL ACTIVITY OF SOME 4-SUBSTITUTED CURCUM1N DERIVATIVES
title_full	SYNTHESIS AND BIOLOGICAL ACTIVITY OF SOME 4-SUBSTITUTED CURCUM1N DERIVATIVES
title_fullStr	SYNTHESIS AND BIOLOGICAL ACTIVITY OF SOME 4-SUBSTITUTED CURCUM1N DERIVATIVES
title_full_unstemmed	SYNTHESIS AND BIOLOGICAL ACTIVITY OF SOME 4-SUBSTITUTED CURCUM1N DERIVATIVES
title_sort	synthesis and biological activity of some 4-substituted curcum1n derivatives
publisher	[Yogyakarta] : Universitas Gadjah Mada
publishDate	2000
url	https://repository.ugm.ac.id/23019/ http://i-lib.ugm.ac.id/jurnal/download.php?dataId=5947
_version_	1681218130374819840

SYNTHESIS AND BIOLOGICAL ACTIVITY OF SOME 4-SUBSTITUTED CURCUM1N DERIVATIVES

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