POLIMORFISME GENETIK G894TNOS3, A1408G ICAM-1, SEBAGAI FAKTOR PREOISPOSISI GASTROSISIS ETNIS JAWA 01 RSUP DR SAROJITO, YOGYAKARTA

• Main Author: , Akhmad Makhmudi
• Format: Article NonPeerReviewed
• Published: [Yogyakarta] : Lembaga Penelitian dan Pengabdian Kepada Masyaraka 2009
• Online Access: https://repository.ugm.ac.id/95218/; http://repository.ugm.ac.id/digitasi/index.php?module=cari_hasil_full&idbuku=3036
• Institution: Universitas Gadjah Mada

<p>Gastroschisis is a severe birth defect congenital disruption characteristic by herniation of intraabdominal organs caused by paraumbilical defect of the abdominal wall, usually to the right of the umbilical cord. The pathogenesis of gastroschisis in still unknown, but prevailing hypothesis is genetic factors may play an important role. In this study, we analyzed the A1408G ICAM-1 and G894T NOS3 polymorphism among another C677T 5,1O-MethyJenetetrahydrofotateredUdase(MTHFR) , G2021 0 prothrombine and GS06A factor V Leiden polymorphisme, that all presumptive as predisposition gastroschisis patients in Sardjito Hospital, Yogyakarta.<br /> Thirty seven patients with gastroschisis attended Sardjito Hospital during 2007-2009 were enrolled in this study as patient's group. Blood samples were withdrawn after obtained informed consent The A1408G ICAM-1 and G894T NOS3 polymorphism were analyzed by use of PCR-RFLP method. The genotype and allele frequency of A 1408G ICAM-1 and G894T NOS3 polymophism from non-gastroschisis patient whose mothers were matched by maternal age and Jawa etnic served as control neonates. The difference between groups was analyzed by chi-square test.<br /> The result of the matching case-control test analysis revealed no association of the A1408G ICAM-1 and G894T NOS3 polymorphism with gastroschisis. Both 37 gastroschisis patients, the A1408G ICAM-1 frequency M, AG and GG genotypes were 2S, 11 and 1, respectively, whereas in control were 1S, 19 and 3, respectively. There was no significant difference of genotype frequency between gastroschisis and control (p&lt