EKSPRESI Ki-67 DAN PROGESTERON RESEPTOR PADA BERBAGAI DERAJAT DIFFERENSIASI HISTOPATOLOGI MENINGIOMA
Background Meningioma is the most intracranial tumor in human. Eventhough most of cases are benign meningioma that can be treated with surgical resection, some of cases show recurrency and poor prognosis. Meningioma histopathological feature is an aggresivity predictor. Certain biomarker consisting...
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Main Authors: | , |
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Format: | Theses and Dissertations NonPeerReviewed |
Published: |
[Yogyakarta] : Universitas Gadjah Mada
2012
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Subjects: | |
Online Access: | https://repository.ugm.ac.id/97699/ http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=54187 |
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Institution: | Universitas Gadjah Mada |
Summary: | Background
Meningioma is the most intracranial tumor in human. Eventhough most of cases are benign
meningioma that can be treated with surgical resection, some of cases show recurrency and poor
prognosis. Meningioma histopathological feature is an aggresivity predictor. Certain biomarker
consisting of Ki-67 protein expression and progesterone receptor, can be developed as a factor to
predict tumor recurrence and progression possibility in meningioma patient.
Objective
The aim of this study is to investigate the correlation between Ki-67, progesteron receptor, expression
and histopatological grade based on WHO criteria.
Method
Research subjects were taken from meningioma 39 cases of meningioma in Anatomical Pathology
Laboratory Sardjito Hospital from 2006 until 2011.
Parrafin block sections were stained with hematoxyllin eosin, then the histopathological features were
observed and meningioma differentiation grade were concluded using WHO criteria by Anatomical
Pathology expert. Finally, immunohistochemical staining of Ki 67, progesterone receptor, and was
performed Kruskal Wallis Correlation was used to analyze the data.
Result
There is a weak correlation between Ki-67 immunoreactivity and hitopathological grades of
meningioma, but it was statistically insignificant (p = 0.614). Most of meningioma express
progesterone receptors ( 74,4%). But the expression of progesterone receptor was insignificantly
associated with histopathological grade of meningioma (p=0.575).
Conclusion
There is weak positive correlation between Ki-67 immunoreactivity and histological grade of
meningioma although it was statistically insignificant. There was also no significant correlation
between progesterone receptor expression and histopathological grade of meningioma. |
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