Hubungan antara Ekspresi Protein NM23-H1, Densitas Limfovaskuler Peritumoral dan Invasi Limfovaskuler dengan Stadium dan Diferensiasi Histopatologi Adenokarsinoma Kolorektal
One of the causes of Background: recurrence of colorectal carcinoma due to loco regional or distant metastasis. NM23-H1 is one of metastasis suppressor gene, and many studies showed that the correlation of NM23-H1 expression and lymphovascular invasion to the grading and staging of colorectal carcin...
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Main Authors: | , |
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Format: | Theses and Dissertations NonPeerReviewed |
Published: |
[Yogyakarta] : Universitas Gadjah Mada
2012
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Subjects: | |
Online Access: | https://repository.ugm.ac.id/99960/ http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=56304 |
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Institution: | Universitas Gadjah Mada |
Summary: | One of the causes of Background: recurrence of colorectal carcinoma due to loco regional or
distant metastasis. NM23-H1 is one of metastasis suppressor gene, and many studies showed
that the correlation of NM23-H1 expression and lymphovascular invasion to the grading and
staging of colorectal carcinoma still controversial.
The aim Purpose: of this study is to determine the correlation of NM23-H1 expression and
lymphovascular invasion in the grading and staging of colorectal carcinoma.
A restrospective cross sectional study Methode: , using analytic and observational of 50
paraffin embedded tissue of patient with adenocarcinoma colorectal Duke B and C paraffin
block, which diagnosed as adenocarcinoma colorectal Duke B and C by histopathological
examination in Dr. Sardjito Central General Hospital since 1 January 2007. Those embeded
tissues were cut 4µ and stained by polyclonal antibody against NM23-H1 and monoclonal
antibodi against D2-40. Correlation NM23-H1 with lymphovascular invasion were analyzed
using Spearman test. Chi Square test was performed to analyzed the association of NM23-H1
and lymphovascular invasion with grading and staging of the tumor.
were Result: There significant differences in the aspect of NM23-H1 expression and
lymphovascular invasion in the cases with adenocarcinoma colorectal stage B and C (p: 0,006
and 0,013) |
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