Hubungan antara Ekspresi Protein NM23-H1, Densitas Limfovaskuler Peritumoral dan Invasi Limfovaskuler dengan Stadium dan Diferensiasi Histopatologi Adenokarsinoma Kolorektal

• Main Authors: , Tejo Jayadi, , dr. Harijadi, SpPA(K)
• Format: Theses and Dissertations NonPeerReviewed
• Published: [Yogyakarta] : Universitas Gadjah Mada 2012
• Subjects: ETD
• Online Access: https://repository.ugm.ac.id/99960/; http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=56304
• Institution: Universitas Gadjah Mada

One of the causes of Background: recurrence of colorectal carcinoma due to loco regional or distant metastasis. NM23-H1 is one of metastasis suppressor gene, and many studies showed that the correlation of NM23-H1 expression and lymphovascular invasion to the grading and staging of colorectal carcinoma still controversial. The aim Purpose: of this study is to determine the correlation of NM23-H1 expression and lymphovascular invasion in the grading and staging of colorectal carcinoma. A restrospective cross sectional study Methode: , using analytic and observational of 50 paraffin embedded tissue of patient with adenocarcinoma colorectal Duke B and C paraffin block, which diagnosed as adenocarcinoma colorectal Duke B and C by histopathological examination in Dr. Sardjito Central General Hospital since 1 January 2007. Those embeded tissues were cut 4µ and stained by polyclonal antibody against NM23-H1 and monoclonal antibodi against D2-40. Correlation NM23-H1 with lymphovascular invasion were analyzed using Spearman test. Chi Square test was performed to analyzed the association of NM23-H1 and lymphovascular invasion with grading and staging of the tumor. were Result: There significant differences in the aspect of NM23-H1 expression and lymphovascular invasion in the cases with adenocarcinoma colorectal stage B and C (p: 0,006 and 0,013)