Anti-infective activities of secondary metabolites from Vitex pinnata
The phytochemical investigation of Vitex pinnata led to the isolation of a mixture of steroids く-sitosterol and stigmasterol (1a and 1b) and three known flavonoid identified as 5-hydroxy-3, 7, 4’-trimethoxyflavone (2), 5- hydroxy-7,4’-dimethoxy-flavone (3) and 5-hydroxy-3,3’,4’,7-tetramethoxyflavone...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Open Science Publishers LLP Inc.
2016
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| Subjects: | |
| Online Access: | http://eprints.unisza.edu.my/7178/1/FH02-FBIM-16-05379.jpg http://eprints.unisza.edu.my/7178/ |
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| Institution: | Universiti Sultan Zainal Abidin |
| Language: | English |
| Summary: | The phytochemical investigation of Vitex pinnata led to the isolation of a mixture of steroids く-sitosterol and stigmasterol (1a and 1b) and three known flavonoid identified as 5-hydroxy-3, 7, 4’-trimethoxyflavone (2), 5- hydroxy-7,4’-dimethoxy-flavone (3) and 5-hydroxy-3,3’,4’,7-tetramethoxyflavone (4). The structures of all isolated compounds were carried out by NMR and mass spectrometry. The isolated compounds were evaluated for their anti-infective activities against Trypanosoma brucei brucei and Mycobacterium marinum. Compound 1- 4 showed moderate antitrypanosomal activity with MIC values of 6.25たg/ml, 19.0, 21.0 and 17.0たM, respectively while no activity observed on anti-mycobacterial. This study is the first to report the presence of three flavones and their antitrypanosomal activity from V. pinnata. |
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