Anti-infective activities of secondary metabolites from Vitex pinnata

• Main Authors: Nurkhalida, Kamal, Ruangelie, Edrada-Ebel, Carol, Clements
• Format: Article
• Language: English
• Published: Open Science Publishers LLP Inc. 2016
• Subjects: QD Chemistry; QH301 Biology
• Online Access: http://eprints.unisza.edu.my/7178/1/FH02-FBIM-16-05379.jpg; http://eprints.unisza.edu.my/7178/
• Institution: Universiti Sultan Zainal Abidin

The phytochemical investigation of Vitex pinnata led to the isolation of a mixture of steroids く-sitosterol and stigmasterol (1a and 1b) and three known flavonoid identified as 5-hydroxy-3, 7, 4’-trimethoxyflavone (2), 5- hydroxy-7,4’-dimethoxy-flavone (3) and 5-hydroxy-3,3’,4’,7-tetramethoxyflavone (4). The structures of all isolated compounds were carried out by NMR and mass spectrometry. The isolated compounds were evaluated for their anti-infective activities against Trypanosoma brucei brucei and Mycobacterium marinum. Compound 1- 4 showed moderate antitrypanosomal activity with MIC values of 6.25たg/ml, 19.0, 21.0 and 17.0たM, respectively while no activity observed on anti-mycobacterial. This study is the first to report the presence of three flavones and their antitrypanosomal activity from V. pinnata.