Possible origin of electronic effects in Rh(I)-catalyzed enantioselective hydrogenation

• Main Authors: Wu, Hai-Chen, Abd Hamid, Shafida, Yu, Jin-Quan, Spencer, Jonathan B
• Format: Article
• Language: English
• Published: American Chemical Society 2009
• Subjects: QD Chemistry
• Online Access: http://irep.iium.edu.my/10332/1/sw-2.pdf; http://irep.iium.edu.my/10332/; http://pubs.acs.org/doi/abs/10.1021/ja903089f
• Institution: Universiti Islam Antarabangsa Malaysia

Reducing the electron density of ligands switches the regioselectivity of Rh(I)-catalyzed hydrometalation. A reversal of the sense of chiral induction was also observed when chiral ligands are electronically tuned in the same manner. The combined data provide an alternative rationale for the electro...