Defect in serine 46 phosphorylation of p53 contributes to acquisition of p53 resistance in oral squamous cell carcinoma cells

Defect in serine 46 phosphorylation of p53 contributes to acquisition of p53 resistance in oral squamous cell carcinoma cells

To investigate whether dysregulation of p53 phosphorylation confers tumor resistance to p53, we analysed the effects of wild-type p53 on oral squamous cell carcinoma(SCC) cell lines carrying various mutations of p53. Introduction of exogenous p53 neither induced apoptosis nor suppressed colony form...

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Bibliographic Details
Main Authors: Arief Ichwan, Solachuddin Jauhari, Shumpei, Yamada, Piyamas, Sumrejkanchanakij, Elza, Ibrahim-Auerkari, K, Eto, Ikeda, Masa-Aki
Format: Article
Language:English
Published: Nature 2006
Subjects:
R Medicine (General)
Online Access:http://irep.iium.edu.my/4137/1/1209158a.pdf
http://irep.iium.edu.my/4137/
http://www.nature.com/onc/index.html
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Institution: Universiti Islam Antarabangsa Malaysia
Language: English

Internet

http://irep.iium.edu.my/4137/1/1209158a.pdf
http://irep.iium.edu.my/4137/
http://www.nature.com/onc/index.html

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