Defect in serine 46 phosphorylation of p53 contributes to acquisition of p53 resistance in oral squamous cell carcinoma cells

• Main Authors: Arief Ichwan, Solachuddin Jauhari, Shumpei, Yamada, Piyamas, Sumrejkanchanakij, Elza, Ibrahim-Auerkari, K, Eto, Ikeda, Masa-Aki
• Format: Article
• Language: English
• Published: Nature 2006
• Subjects: R Medicine (General)
• Online Access: http://irep.iium.edu.my/4137/1/1209158a.pdf; http://irep.iium.edu.my/4137/; http://www.nature.com/onc/index.html
• Institution: Universiti Islam Antarabangsa Malaysia

To investigate whether dysregulation of p53 phosphorylation confers tumor resistance to p53, we analysed the effects of wild-type p53 on oral squamous cell carcinoma(SCC) cell lines carrying various mutations of p53. Introduction of exogenous p53 neither induced apoptosis nor suppressed colony form...