Synthesis, Characterization and Antioxidant Activity of 2-Halobenzoyl Thiourea Bearing α- and β-alanine

• Main Authors: Ngah, Nurziana, Mohamed, Nor Azanita, Darnis, Deny Susanti
• Format: Article
• Language: English; English; English
• Published: Chiang Mai University 2016
• Subjects: QD Chemistry
• Online Access: http://irep.iium.edu.my/46121/4/16-03-22-d490d.pdf; http://irep.iium.edu.my/46121/7/46121_Synthesis%2C%20Characterization%20and%20Antioxidant%20Activity%20of%202-Halobenzoyl_Scopus.pdf; http://irep.iium.edu.my/46121/13/46121_Synthesis%2C%20characterization%20and%20antioxidant%20activity_wos.pdf; http://irep.iium.edu.my/46121/; http://it.science.cmu.ac.th/ejournal/journalDetail.php?journal_id=6816
• Institution: Universiti Islam Antarabangsa Malaysia

Six new 2-halobenzoylthiourea compounds bearing α- and β-alanine have been successfully synthesized and characterized using CHNS microelemental analysis and spectroscopic methods including FTIR, UV-Vis and NMR. Microelemental analysis data of the compounds were in agreement with the theoretical values. The FTIR spectra showed the presence of important bands of the compounds while the 1 H-NMR and 13C-NMR exhibited the expected chemical shifts. The compounds exerted weak antioxidant activity in DPPH scavenging test and moderate to good activity in β-carotene bleaching test. The inclusion of halogen atoms has facilitated the released of hydrogen atoms and introduction of α- and β-alanine have increased the β-carotene bleaching and DPPH scavenging activities of the compounds.