Intra-articular injection of chondrogenic induced bone marrow stem cells in a sheep model

• Main Authors: Alfaqeh, Hamoud Hussein Mohammed, Idrus, Ruszymah, yahya, norhamdan, Chen, Hui Cheng, Saim, Aminuddin
• Format: Conference or Workshop Item
• Language: English
• Published: 2012
• Subjects: RD701 Orthopedics
• Online Access: http://irep.iium.edu.my/46455/1/upm_conference_2012.jpg; http://irep.iium.edu.my/46455/; http://vet.upm.edu.my/vam2012.html
• Institution: Universiti Islam Antarabangsa Malaysia

In recent year, the use of bone marrow mesenchymal stem cells (BMSCs) implantation has provided an alternative treatment for osteoarthritis ( OA). The objective of this study is to determine whether or not an intra-articular injection of a single dose of autologus chondrogenic induced BMSCs could retard the progressive destruction of cartilage in a surgically induced osteoarthritis in a sheep. from our findings it is suggested that an intra-articular injection into OA knee joints of sheep with autologus bone marrow stem cells cultured in chondrogenic medium has possibility of retarding the progression of OA.