CYP2C9 polymorphism: prevalence in healthy and warfarin-treated Malay and Chinese in Malaysia
Introduction: Genetic polymorphisms of CYP2C9 among different populations in different geographical regions could be dif ferent . CYP2C9 has been reported to be the enzyme responsible for the metabolism of many drugs, including warfarin and other drugs with a narrow therapeutic index. Realisin...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Singapore Medical Association
2009
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/5194/1/CYP2C9_Poly_in_SMJ_2009.pdf http://irep.iium.edu.my/5194/ http://smj.sma.org.sg/5005/5005a6.pdf |
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| Institution: | Universiti Islam Antarabangsa Malaysia |
| Language: | English |
| Summary: | Introduction: Genetic polymorphisms of
CYP2C9 among different populations in different
geographical regions could be dif ferent .
CYP2C9 has been reported to be the enzyme
responsible for the metabolism of many drugs,
including warfarin and other drugs with a narrow
therapeutic index. Realising the importance of
inter-individual differences in the genetic profile
in determining the outcome of a drug therapy,
this study was conducted to explore the types
and frequencies of CYP2C9 alleles in healthy
and warfarin-treated Malays and Chinese, the
two major ethnic groups in Malaysia. We aimed
to evaluate the prevalence of the types and
frequencies of common CYP2C9 alleles (*1, *2, *3
and *4) among the healthy unrelated individuals
and diseased patients prescribed with warfarin. |
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