CYP2C9 polymorphism: prevalence in healthy and warfarin-treated Malay and Chinese in Malaysia
Introduction: Genetic polymorphisms of CYP2C9 among different populations in different geographical regions could be dif ferent . CYP2C9 has been reported to be the enzyme responsible for the metabolism of many drugs, including warfarin and other drugs with a narrow therapeutic index. Realisin...
Saved in:
Main Authors: | , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Singapore Medical Association
2009
|
Subjects: | |
Online Access: | http://irep.iium.edu.my/5194/1/CYP2C9_Poly_in_SMJ_2009.pdf http://irep.iium.edu.my/5194/ http://smj.sma.org.sg/5005/5005a6.pdf |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Institution: | Universiti Islam Antarabangsa Malaysia |
Language: | English |
id |
my.iium.irep.5194 |
---|---|
record_format |
dspace |
spelling |
my.iium.irep.51942011-11-18T02:10:32Z http://irep.iium.edu.my/5194/ CYP2C9 polymorphism: prevalence in healthy and warfarin-treated Malay and Chinese in Malaysia Ngow, Harris Abdullah Wan Khairina, Wan Mohd Nowalid Teh , Lay Kek Lee, Wee Leng Harun, Roslan Ismail, Rusli Salleh, Mohd Zaki RC Internal medicine RM Therapeutics. Pharmacology Introduction: Genetic polymorphisms of CYP2C9 among different populations in different geographical regions could be dif ferent . CYP2C9 has been reported to be the enzyme responsible for the metabolism of many drugs, including warfarin and other drugs with a narrow therapeutic index. Realising the importance of inter-individual differences in the genetic profile in determining the outcome of a drug therapy, this study was conducted to explore the types and frequencies of CYP2C9 alleles in healthy and warfarin-treated Malays and Chinese, the two major ethnic groups in Malaysia. We aimed to evaluate the prevalence of the types and frequencies of common CYP2C9 alleles (*1, *2, *3 and *4) among the healthy unrelated individuals and diseased patients prescribed with warfarin. Singapore Medical Association 2009 Article REM application/pdf en http://irep.iium.edu.my/5194/1/CYP2C9_Poly_in_SMJ_2009.pdf Ngow, Harris Abdullah and Wan Khairina, Wan Mohd Nowalid and Teh , Lay Kek and Lee, Wee Leng and Harun, Roslan and Ismail, Rusli and Salleh, Mohd Zaki (2009) CYP2C9 polymorphism: prevalence in healthy and warfarin-treated Malay and Chinese in Malaysia. Singapore Medical Journal, 50 (5). pp. 490-493. ISSN 0037-5675 http://smj.sma.org.sg/5005/5005a6.pdf |
institution |
Universiti Islam Antarabangsa Malaysia |
building |
IIUM Library |
collection |
Institutional Repository |
continent |
Asia |
country |
Malaysia |
content_provider |
International Islamic University Malaysia |
content_source |
IIUM Repository (IREP) |
url_provider |
http://irep.iium.edu.my/ |
language |
English |
topic |
RC Internal medicine RM Therapeutics. Pharmacology |
spellingShingle |
RC Internal medicine RM Therapeutics. Pharmacology Ngow, Harris Abdullah Wan Khairina, Wan Mohd Nowalid Teh , Lay Kek Lee, Wee Leng Harun, Roslan Ismail, Rusli Salleh, Mohd Zaki CYP2C9 polymorphism: prevalence in healthy and warfarin-treated Malay and Chinese in Malaysia |
description |
Introduction: Genetic polymorphisms of
CYP2C9 among different populations in different
geographical regions could be dif ferent .
CYP2C9 has been reported to be the enzyme
responsible for the metabolism of many drugs,
including warfarin and other drugs with a narrow
therapeutic index. Realising the importance of
inter-individual differences in the genetic profile
in determining the outcome of a drug therapy,
this study was conducted to explore the types
and frequencies of CYP2C9 alleles in healthy
and warfarin-treated Malays and Chinese, the
two major ethnic groups in Malaysia. We aimed
to evaluate the prevalence of the types and
frequencies of common CYP2C9 alleles (*1, *2, *3
and *4) among the healthy unrelated individuals
and diseased patients prescribed with warfarin. |
format |
Article |
author |
Ngow, Harris Abdullah Wan Khairina, Wan Mohd Nowalid Teh , Lay Kek Lee, Wee Leng Harun, Roslan Ismail, Rusli Salleh, Mohd Zaki |
author_facet |
Ngow, Harris Abdullah Wan Khairina, Wan Mohd Nowalid Teh , Lay Kek Lee, Wee Leng Harun, Roslan Ismail, Rusli Salleh, Mohd Zaki |
author_sort |
Ngow, Harris Abdullah |
title |
CYP2C9 polymorphism: prevalence in healthy and warfarin-treated Malay and Chinese in Malaysia |
title_short |
CYP2C9 polymorphism: prevalence in healthy and warfarin-treated Malay and Chinese in Malaysia |
title_full |
CYP2C9 polymorphism: prevalence in healthy and warfarin-treated Malay and Chinese in Malaysia |
title_fullStr |
CYP2C9 polymorphism: prevalence in healthy and warfarin-treated Malay and Chinese in Malaysia |
title_full_unstemmed |
CYP2C9 polymorphism: prevalence in healthy and warfarin-treated Malay and Chinese in Malaysia |
title_sort |
cyp2c9 polymorphism: prevalence in healthy and warfarin-treated malay and chinese in malaysia |
publisher |
Singapore Medical Association |
publishDate |
2009 |
url |
http://irep.iium.edu.my/5194/1/CYP2C9_Poly_in_SMJ_2009.pdf http://irep.iium.edu.my/5194/ http://smj.sma.org.sg/5005/5005a6.pdf |
_version_ |
1643605489373675520 |