Inhibitors of leishmania mexicana phosphoglycerate mutase identified by virtual screening and verified by inhibition studies

• Main Authors: Ahmad Fuad, Fazia Adyani, Houston, Douglas Robert, Michels, Paul A M, Fothergill- Gilmore, Linda A., Walkinshaw, Malcolm Douglas
• Format: Article
• Language: English; English; English
• Published: Penerbit Universiti Kebangsaan Malaysia 2016
• Subjects: TA Engineering (General). Civil engineering (General); TA164 Bioengineering
• Online Access: http://irep.iium.edu.my/53866/1/53866_Inhibitors%20of%20Leishmania.pdf; http://irep.iium.edu.my/53866/2/53866_Inhibitors%20of%20Leishmania_WOS.pdf; http://irep.iium.edu.my/53866/4/53866_Inhibitors%20of%20Leishmania_SCOPUS.pdf; http://irep.iium.edu.my/53866/; http://journalarticle.ukm.my/9986/1/14%20Fazia%20Adyani.pdf
• Institution: Universiti Islam Antarabangsa Malaysia

Cofactor-independent phosphoglycerate mutase has been proposed as a therapeutic target for the treatment of trypanosomatid diseases. In this paper, we report the identification of compounds that could potentially be developed as selective inhibitors of cofactor-independent phosphoglycerate mutase fr...