Suramin inhibits PDGF-stimulated receptor phosphorylation, proteoglycan synthesis and glycosaminoglycan hyperelongation in human vascular smooth muscle cells

Suramin inhibits PDGF-stimulated receptor phosphorylation, proteoglycan synthesis and glycosaminoglycan hyperelongation in human vascular smooth muscle cells

Objectives Suramin is a polysulfonated naphthylurea with antiparasitic and potential antineoplastic activity. Suramin’s pharmacological actions, which have not yet been fully elucidated, include antagonism of the action of platelet-derived growth factor (PDGF) at its receptor. We investigated the...

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Bibliographic Details
Main Authors: Little, Peter J., Rostam, Muhamad Ashraf, Piva, Terence J., Getachew, Robel, Kamato, Danielle, Guidone, Daniel, Ballinger, Mandy L., Zheng, Wenhua, Osman, Narin
Format: Article
Language:English
Published: Wiley 2013
Subjects:
QP Physiology
RM Therapeutics. Pharmacology
Online Access:http://irep.iium.edu.my/55280/1/7.%20Little-2013-Suramin%20inhibits%20PDGF-stimulated%20r.pdf
http://irep.iium.edu.my/55280/
http://onlinelibrary.wiley.com/doi/10.1111/jphp.12064/abstract
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Institution: Universiti Islam Antarabangsa Malaysia
Language: English

Internet

http://irep.iium.edu.my/55280/1/7.%20Little-2013-Suramin%20inhibits%20PDGF-stimulated%20r.pdf
http://irep.iium.edu.my/55280/
http://onlinelibrary.wiley.com/doi/10.1111/jphp.12064/abstract

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