Suramin inhibits PDGF-stimulated receptor phosphorylation, proteoglycan synthesis and glycosaminoglycan hyperelongation in human vascular smooth muscle cells

• Main Authors: Little, Peter J., Rostam, Muhamad Ashraf, Piva, Terence J., Getachew, Robel, Kamato, Danielle, Guidone, Daniel, Ballinger, Mandy L., Zheng, Wenhua, Osman, Narin
• Format: Article
• Language: English
• Published: Wiley 2013
• Subjects: QP Physiology; RM Therapeutics. Pharmacology
• Online Access: http://irep.iium.edu.my/55280/1/7.%20Little-2013-Suramin%20inhibits%20PDGF-stimulated%20r.pdf; http://irep.iium.edu.my/55280/; http://onlinelibrary.wiley.com/doi/10.1111/jphp.12064/abstract
• Institution: Universiti Islam Antarabangsa Malaysia

Objectives Suramin is a polysulfonated naphthylurea with antiparasitic and potential antineoplastic activity. Suramin’s pharmacological actions, which have not yet been fully elucidated, include antagonism of the action of platelet-derived growth factor (PDGF) at its receptor. We investigated the...