Role of sirtuin 1 (SIRT1) in regulation of autophagy and nuclear factor-kappa Beta (NF-ĸβ) pathways in sorafenib-resistant hepatocellular carcinoma (HCC)

• Main Authors: Chan, Hui-Yin *, Thamil Selvee, Ramasamy, Chung, Felicia Fei Lei *, Teow, Sin Yeang *
• Format: Article
• Published: Springer 2024
• Subjects: QP Physiology; RC Internal medicine
• Online Access: http://eprints.sunway.edu.my/2592/; https://doi.org/10.1007/s12013-024-01247-3
• Institution: Sunway University

Hepatocellular carcinoma (HCC) remains a major global health problem with high incidence and mortality. Diagnosis of HCC at late stages and tumour heterogeneity in patients with different genetic profiles are known factors that complicate the disease treatment. HCC therapy becomes even more challeng...