Spectaflavoside A, a new potent iron chelating dimeric flavonol glycoside from the rhizomes of Zingiber spectabile Griff

• Main Author: Leong, K.H.
• Format: Article
• Language: English
• Published: Elsevier 2012
• Subjects: Q Science (General); QD Chemistry; QH301 Biology; QK Botany; R Medicine; RM Therapeutics. Pharmacology; RS Pharmacy and materia medica; RV Botanic, Thomsonian, and eclectic medicine
• Online Access: http://eprints.um.edu.my/10000/1/1Spectaflavoside_A%2C_a_new_potent_iron_chelating_dimeric_flavonol_glycoside_from_the_rhizomes_of_Zingiber_spectabile_Griff..pdf; http://eprints.um.edu.my/10000/; http://www.sciencedirect.com/science/article/pii/S0960894X12002569
• Institution: Universiti Malaya

The rhizomes of Zingiber spectabile yielded a new dimeric flavonol glycoside for which the name kaempferol-3-O-(4″-O-acetyl)-α-l-rhamnopyranoside-(I-6,II-8)-kaempferol-3-O-(4″-O-acetyl)-α-l-rhamnopyranoside; spectaflavoside A (1) was proposed, along with kaempferol and its four acetylrhamnosides (2–6), demethoxycurcumin (7) and curcumin (8). The structure of spectaflavoside A was elucidated by spectroscopic methods including, 1D and 2D NMR techniques. This is the first report on the occurrence of a dimeric flavonol glycoside in the Zingiberaceae and the second in nature. Spectaflavoside A was found to be a potent iron chelating agent.