Arboridinine, a Pentacyclic Indole Alkaloid with a New Cage Carbon–Nitrogen Skeleton Derived from a Pericine Precursor

• Main Authors: Wong, S.P., Gan, C.Y., Lim, K.H., Ting, K.N., Low, Y.Y., Kam, T.S.
• Format: Article
• Published: American Chemical Society 2015
• Subjects: Q Science (General); QA75 Electronic computers. Computer science; QD Chemistry; R Medicine; TA Engineering (General). Civil engineering (General)
• Online Access: http://eprints.um.edu.my/19443/; http://dx.doi.org/10.1021/acs.orglett.5b01757
• Institution: Universiti Malaya

A new monoterpene indole alkaloid characterized by an unprecedented pentacyclic cage skeleton, arboridinine (1), was isolated from a Malaysian Kopsia species. The structure and absolute configuration of the alkaloid were determined based on NMR, MS, and X-ray diffraction analysis. A possible biogene...