Fucosterol inhibits the cholinesterase activities and reduces the release of pro-inflammatory mediators in lipopolysaccharide and amyloid-induced microglial cells

• Main Authors: Wong, Chun Hoong, Gan, Sook Yee, Tan, Swee Ching, Gany, Siti Aisya, Ying, Tiong, Gray, Alexander Irvine, Igoli, John, Chan, Elaine Wan Ling, Phang, Siew Moi
• Format: Article
• Published: Springer Verlag 2018
• Subjects: Q Science (General); QH Natural history
• Online Access: http://eprints.um.edu.my/20373/; https://doi.org/10.1007/s10811-018-1495-1
• Institution: Universiti Malaya

According to the cholinergic hypothesis, memory impairment in patients with Alzheimer’s disease (AD) is associated with the deficit of cholinergic function in the brain. In addition, microglial activation plays an important role in AD by producing pro-inflammatory cytokines, nitric oxide (NO), and p...