Saccharin: an efficient organocatalyst for the one-pot synthesis of 4-amidocinnolines under metal and halogen-free conditions

A mild and efficient protocol for the one-pot synthesis of 4-amidocinnolines was developed using saccharin as a cheap and eco-friendly organocatalyst and t-butyl nitrite as a metal-free diazotization reagent. The current method has advantages such as cost effectiveness, use of the biodegradable reag...

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Main Authors:	Khaligh, Nader Ghaffari, Mihankhah, Taraneh, Johan, Mohd Rafie, Juan, Joon Ching
Format:	Article
Published:	Springer Verlag 2018
Subjects:	QD Chemistry TA Engineering (General). Civil engineering (General)
Online Access:	http://eprints.um.edu.my/21639/ https://doi.org/10.1007/s00706-018-2174-2
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Institution:	Universiti Malaya

id	my.um.eprints.21639
record_format	eprints
spelling	my.um.eprints.216392019-07-16T08:14:08Z http://eprints.um.edu.my/21639/ Saccharin: an efficient organocatalyst for the one-pot synthesis of 4-amidocinnolines under metal and halogen-free conditions Khaligh, Nader Ghaffari Mihankhah, Taraneh Johan, Mohd Rafie Juan, Joon Ching QD Chemistry TA Engineering (General). Civil engineering (General) A mild and efficient protocol for the one-pot synthesis of 4-amidocinnolines was developed using saccharin as a cheap and eco-friendly organocatalyst and t-butyl nitrite as a metal-free diazotization reagent. The current method has advantages such as cost effectiveness, use of the biodegradable reagents, simple experimental procedure; afford the quantitative yield of the desired products, metal- and halogen-free as well as environmentally benign conditions. Springer Verlag 2018 Article PeerReviewed Khaligh, Nader Ghaffari and Mihankhah, Taraneh and Johan, Mohd Rafie and Juan, Joon Ching (2018) Saccharin: an efficient organocatalyst for the one-pot synthesis of 4-amidocinnolines under metal and halogen-free conditions. Monatshefte fur Chemie - Chemical Monthly, 149 (6). pp. 1083-1087. ISSN 0026-9247 https://doi.org/10.1007/s00706-018-2174-2 doi:10.1007/s00706-018-2174-2
institution	Universiti Malaya
building	UM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Malaya
content_source	UM Research Repository
url_provider	http://eprints.um.edu.my/
topic	QD Chemistry TA Engineering (General). Civil engineering (General)
spellingShingle	QD Chemistry TA Engineering (General). Civil engineering (General) Khaligh, Nader Ghaffari Mihankhah, Taraneh Johan, Mohd Rafie Juan, Joon Ching Saccharin: an efficient organocatalyst for the one-pot synthesis of 4-amidocinnolines under metal and halogen-free conditions
description	A mild and efficient protocol for the one-pot synthesis of 4-amidocinnolines was developed using saccharin as a cheap and eco-friendly organocatalyst and t-butyl nitrite as a metal-free diazotization reagent. The current method has advantages such as cost effectiveness, use of the biodegradable reagents, simple experimental procedure; afford the quantitative yield of the desired products, metal- and halogen-free as well as environmentally benign conditions.
format	Article
author	Khaligh, Nader Ghaffari Mihankhah, Taraneh Johan, Mohd Rafie Juan, Joon Ching
author_facet	Khaligh, Nader Ghaffari Mihankhah, Taraneh Johan, Mohd Rafie Juan, Joon Ching
author_sort	Khaligh, Nader Ghaffari
title	Saccharin: an efficient organocatalyst for the one-pot synthesis of 4-amidocinnolines under metal and halogen-free conditions
title_short	Saccharin: an efficient organocatalyst for the one-pot synthesis of 4-amidocinnolines under metal and halogen-free conditions
title_full	Saccharin: an efficient organocatalyst for the one-pot synthesis of 4-amidocinnolines under metal and halogen-free conditions
title_fullStr	Saccharin: an efficient organocatalyst for the one-pot synthesis of 4-amidocinnolines under metal and halogen-free conditions
title_full_unstemmed	Saccharin: an efficient organocatalyst for the one-pot synthesis of 4-amidocinnolines under metal and halogen-free conditions
title_sort	saccharin: an efficient organocatalyst for the one-pot synthesis of 4-amidocinnolines under metal and halogen-free conditions
publisher	Springer Verlag
publishDate	2018
url	http://eprints.um.edu.my/21639/ https://doi.org/10.1007/s00706-018-2174-2
_version_	1643691617465401344

Saccharin: an efficient organocatalyst for the one-pot synthesis of 4-amidocinnolines under metal and halogen-free conditions

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