Facile Intramolecular Cyclization of N -(2-Hydroxybenzoyl)hydrazones to N ,N′ -Diacetyl Benzo-1,3,4-oxadiazepine Derivatives
A facile synthesis of seven-membered benzo-1,3,4-oxadiazepines through one-step intramolecular cyclization of N-(2-hydroxybenzoyl)hydrazones has been established. The catalytic and substituent effects on the reactivity of this intramolecular cyclization were investigated. Through this strategy, a se...
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| Main Authors: | , , |
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| Format: | Article |
| Published: |
Wiley-VCH Verlag
2018
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| Subjects: | |
| Online Access: | http://eprints.um.edu.my/22279/ https://doi.org/10.1002/ajoc.201800014 |
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| Institution: | Universiti Malaya |
| Summary: | A facile synthesis of seven-membered benzo-1,3,4-oxadiazepines through one-step intramolecular cyclization of N-(2-hydroxybenzoyl)hydrazones has been established. The catalytic and substituent effects on the reactivity of this intramolecular cyclization were investigated. Through this strategy, a series of benzo-1,3,4-oxadiazepine derivatives were prepared (with yields up to 83 %). |
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