Lignosus rhinocerus TM02® sclerotia extract inhibits dengue virus replication and Infection
Lignosus rhinocerus (L. rhinocerus) is a rare in Southeast Asia and has been long used by the natives for various medicinal purposes. In the advent of the mushroom's successful cultivation, a novel cultivar, named L.rhinocerus TM02®, was produced and has been tested for anti-inflammatory, anti-...
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| Main Authors: | , , , |
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| Format: | Article |
| Published: |
Elsevier
2021
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| Subjects: | |
| Online Access: | http://eprints.um.edu.my/26091/ https://doi.org/10.1016/j.hermed.2021.100505 |
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| Institution: | Universiti Malaya |
| Summary: | Lignosus rhinocerus (L. rhinocerus) is a rare in Southeast Asia and has been long used by the natives for various medicinal purposes. In the advent of the mushroom's successful cultivation, a novel cultivar, named L.rhinocerus TM02®, was produced and has been tested for anti-inflammatory, anti-proliferative, antioxidant, and other medicinal properties. However, the antiviral effects of TM02® cultivar have not been demonstrated. In this study, the antiviral properties of cold-water extract (CWE) from the sclerotium of L.rhinocerus TM02® cultivar were investigated, in inhibiting dengue serotype 2 infection in Vero cells. The authors observed a dose-dependent inhibition on dengue virus replication, particularly during the early stage of dengue infection. The extract also exhibited a significant virucidal effect and displayed a mild prophylactic effect. Hence, in the absence of anti-dengue treatment and limited dengue vaccination, these results indicate that TM02® CWE may serve as an alternative medicine in reducing dengue infection. Further studies are required to identify and verify the bioactive compounds of TM02® CWE that mediate the antiviral activity. © 2021 Elsevier GmbH |
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