Lignosus rhinocerus TM02® sclerotia extract inhibits dengue virus replication and Infection

• Main Authors: Khazali, Ahmad Suhail, Nor Rashid, Nurshamimi, Fung, Shin Yee, Yusof, Rohana
• Format: Article
• Published: Elsevier 2021
• Subjects: R Medicine
• Online Access: http://eprints.um.edu.my/26091/; https://doi.org/10.1016/j.hermed.2021.100505
• Institution: Universiti Malaya

Lignosus rhinocerus (L. rhinocerus) is a rare in Southeast Asia and has been long used by the natives for various medicinal purposes. In the advent of the mushroom's successful cultivation, a novel cultivar, named L.rhinocerus TM02®, was produced and has been tested for anti-inflammatory, anti-proliferative, antioxidant, and other medicinal properties. However, the antiviral effects of TM02® cultivar have not been demonstrated. In this study, the antiviral properties of cold-water extract (CWE) from the sclerotium of L.rhinocerus TM02® cultivar were investigated, in inhibiting dengue serotype 2 infection in Vero cells. The authors observed a dose-dependent inhibition on dengue virus replication, particularly during the early stage of dengue infection. The extract also exhibited a significant virucidal effect and displayed a mild prophylactic effect. Hence, in the absence of anti-dengue treatment and limited dengue vaccination, these results indicate that TM02® CWE may serve as an alternative medicine in reducing dengue infection. Further studies are required to identify and verify the bioactive compounds of TM02® CWE that mediate the antiviral activity. © 2021 Elsevier GmbH