Genome sequencing and phylogenetic reconstruction reveal a potential fourth rhinovirus species and its worldwide distribution

• المؤلفون الرئيسيون: Ng, Kim Tien, Takebe, Yutaka, Kamarulzaman, Adeeba, Tee, Kok Keng
• التنسيق: مقال
• منشور في: Springer Verlag (Germany) 2021
• الموضوعات: R Medicine (General)
• الوصول للمادة أونلاين: http://eprints.um.edu.my/26501/

Genome sequences of members of a potential fourth rhinovirus (RV) species, provisionally denoted as rhinovirus A clade D, from patients with acute respiratory infection were determined. Bayesian coalescent analysis estimated that clade D emerged around the 1940s and diverged further around 2006-2007 into two distinctive sublineages (RV-A8-like and RV-A45-like) that harbored unique ``clade-defining'' substitutions. Similarity plots and bootscan mapping revealed a recombination breakpoint located in the 5MODIFIER LETTER PRIME-UTR region of members of the RV-A8-like sublineage. Phylogenetic reconstruction revealed the distribution of clade D viruses in the Asia Pacific region and in Europe, underlining its worldwide distribution.