Genome sequencing and phylogenetic reconstruction reveal a potential fourth rhinovirus species and its worldwide distribution

Genome sequencing and phylogenetic reconstruction reveal a potential fourth rhinovirus species and its worldwide distribution

Genome sequences of members of a potential fourth rhinovirus (RV) species, provisionally denoted as rhinovirus A clade D, from patients with acute respiratory infection were determined. Bayesian coalescent analysis estimated that clade D emerged around the 1940s and diverged further around 2006-2007...

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Main Authors: Ng, Kim Tien, Takebe, Yutaka, Kamarulzaman, Adeeba, Tee, Kok Keng
Format: Article
Published: Springer Verlag (Germany) 2021
Subjects:
R Medicine (General)
Online Access:http://eprints.um.edu.my/26501/
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Institution: Universiti Malaya
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spelling my.um.eprints.265012022-03-08T08:38:41Z http://eprints.um.edu.my/26501/ Genome sequencing and phylogenetic reconstruction reveal a potential fourth rhinovirus species and its worldwide distribution Ng, Kim Tien Takebe, Yutaka Kamarulzaman, Adeeba Tee, Kok Keng R Medicine (General) Genome sequences of members of a potential fourth rhinovirus (RV) species, provisionally denoted as rhinovirus A clade D, from patients with acute respiratory infection were determined. Bayesian coalescent analysis estimated that clade D emerged around the 1940s and diverged further around 2006-2007 into two distinctive sublineages (RV-A8-like and RV-A45-like) that harbored unique ``clade-defining'' substitutions. Similarity plots and bootscan mapping revealed a recombination breakpoint located in the 5MODIFIER LETTER PRIME-UTR region of members of the RV-A8-like sublineage. Phylogenetic reconstruction revealed the distribution of clade D viruses in the Asia Pacific region and in Europe, underlining its worldwide distribution. Springer Verlag (Germany) 2021-01 Article PeerReviewed Ng, Kim Tien and Takebe, Yutaka and Kamarulzaman, Adeeba and Tee, Kok Keng (2021) Genome sequencing and phylogenetic reconstruction reveal a potential fourth rhinovirus species and its worldwide distribution. Archives of Virology, 166 (1). pp. 225-229. ISSN 0304-8608, DOI https://doi.org/10.1007/s00705-020-04855-5 <https://doi.org/10.1007/s00705-020-04855-5>. 10.1007/s00705-020-04855-5
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic R Medicine (General)
spellingShingle R Medicine (General)
Ng, Kim Tien
Takebe, Yutaka
Kamarulzaman, Adeeba
Tee, Kok Keng
Genome sequencing and phylogenetic reconstruction reveal a potential fourth rhinovirus species and its worldwide distribution
description Genome sequences of members of a potential fourth rhinovirus (RV) species, provisionally denoted as rhinovirus A clade D, from patients with acute respiratory infection were determined. Bayesian coalescent analysis estimated that clade D emerged around the 1940s and diverged further around 2006-2007 into two distinctive sublineages (RV-A8-like and RV-A45-like) that harbored unique ``clade-defining'' substitutions. Similarity plots and bootscan mapping revealed a recombination breakpoint located in the 5MODIFIER LETTER PRIME-UTR region of members of the RV-A8-like sublineage. Phylogenetic reconstruction revealed the distribution of clade D viruses in the Asia Pacific region and in Europe, underlining its worldwide distribution.
format Article
author Ng, Kim Tien
Takebe, Yutaka
Kamarulzaman, Adeeba
Tee, Kok Keng
author_facet Ng, Kim Tien
Takebe, Yutaka
Kamarulzaman, Adeeba
Tee, Kok Keng
author_sort Ng, Kim Tien
title Genome sequencing and phylogenetic reconstruction reveal a potential fourth rhinovirus species and its worldwide distribution
title_short Genome sequencing and phylogenetic reconstruction reveal a potential fourth rhinovirus species and its worldwide distribution
title_full Genome sequencing and phylogenetic reconstruction reveal a potential fourth rhinovirus species and its worldwide distribution
title_fullStr Genome sequencing and phylogenetic reconstruction reveal a potential fourth rhinovirus species and its worldwide distribution
title_full_unstemmed Genome sequencing and phylogenetic reconstruction reveal a potential fourth rhinovirus species and its worldwide distribution
title_sort genome sequencing and phylogenetic reconstruction reveal a potential fourth rhinovirus species and its worldwide distribution
publisher Springer Verlag (Germany)
publishDate 2021
url http://eprints.um.edu.my/26501/
_version_ 1735409420907577344

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