Proteasomal degradation of p130 facilitate cell cycle deregulation and impairment of cellular differentiation in high-risk Human Papillomavirus 16 and 18 E7 transfected cells

The High-Risk Human Papillomaviruses (HR-HPVs) 16 and 18 are known to cause cervical cancer, which is primarily attributed to E6 and E7 oncoproteins. In addition, recent studies have focused on the vital role of the p130 pocket protein as an oncosuppressor to limit the expression of E2F transcriptio...

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Main Authors: Gandhi, Sivasangkary, Nor Rashid, Nurshamimi, Mohamad Razif, Muhammad Fazril, Othman, Shatrah
Format: Article
Published: Springer 2021
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Online Access:http://eprints.um.edu.my/26618/
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Institution: Universiti Malaya