Discovery of small molecule inhibitors against the NS3/4A serine protease of Hepatitis C virus genotype 3 via high-throughput virtual screening and in vitro evaluations

• Main Authors: Sakhor, W., Teoh, T. C., Yusof, R., Lim, S. K., Razif, M. F. M.
• Format: Article
• Published: Malaysian Society for Parasitology 2020
• Subjects: QH301 Biology; R Medicine (General); RS Pharmacy and materia medica
• Online Access: http://eprints.um.edu.my/36458/
• Institution: Universiti Malaya

The hepatitis C virus (HCV) consists of eight genotypes and 90 subtypes, with genotype (GT) 3 being the second most common globally and is linked to higher incidences of steatosis and rapid development of fibrosis and cirrhosis. The NS3/4A serine protease, a heterodimer complex of two HCV non-struct...