Neuronal infection is a major pathogenetic mechanism and cause of fatalities in human acute Nipah virus encephalitis

• Main Authors: Ong, Kien Chai, Ng, Khong Ying, Ng, Chiu Wan, Tan, Soon Hao, Teo, Woon Li, Karim, Norain, Kumar, Shalini, Wong, Kum Thong
• Format: Article
• Published: Wiley 2022
• Subjects: R Medicine; RB Pathology
• Online Access: http://eprints.um.edu.my/41438/
• Institution: Universiti Malaya

Acute Nipah (NiV) encephalitis is characterised by a dual pathogenetic mechanism of neuroglial infection and ischaemia-microinfarction associated with vasculitis-induced thrombotic occlusion. We investigated the contributions of these two mechanisms in fatal cases. Materials and methods We analysed...