Nudix Hydroxylase 15 mutations strongly predict thiopurine-induced leukopenia across different Asian ethnicities: Implications for screening in a diverse population

Nudix Hydroxylase 15 mutations strongly predict thiopurine-induced leukopenia across different Asian ethnicities: Implications for screening in a diverse population

Background and AimsThiopurines, which are immunosuppressive drugs for maintaining remission for inflammatory bowel disease, are known to cause myelotoxicity in patients with Nudix Hydroxylase 15 (NUDT15) genetic variants in some Asian countries with monoethnic populations. We aimed to investigate th...

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Bibliographic Details
Main Authors: Khoo, Xin-Hui, Wong, Shin Yee, Ibrahim, Nik Razima Wan, Ng, Ruey Terng, Chew, Kee Seang, Lee, Way Seah, Wong, Zhi Qin, Raja Ali, Raja Affend, Shahrani, Shahreedhan, Leow, Alex Hwong-Ruey, Hilmi, Ida Normiha
Format: Article
Published: Frontiers Media SA 2022
Subjects:
RC Internal medicine
Online Access:http://eprints.um.edu.my/41541/
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Institution: Universiti Malaya

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http://eprints.um.edu.my/41541/

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