Nudix Hydroxylase 15 mutations strongly predict thiopurine-induced leukopenia across different Asian ethnicities: Implications for screening in a diverse population

• Main Authors: Khoo, Xin-Hui, Wong, Shin Yee, Ibrahim, Nik Razima Wan, Ng, Ruey Terng, Chew, Kee Seang, Lee, Way Seah, Wong, Zhi Qin, Raja Ali, Raja Affend, Shahrani, Shahreedhan, Leow, Alex Hwong-Ruey, Hilmi, Ida Normiha
• Format: Article
• Published: Frontiers Media SA 2022
• Subjects: RC Internal medicine
• Online Access: http://eprints.um.edu.my/41541/
• Institution: Universiti Malaya

Background and AimsThiopurines, which are immunosuppressive drugs for maintaining remission for inflammatory bowel disease, are known to cause myelotoxicity in patients with Nudix Hydroxylase 15 (NUDT15) genetic variants in some Asian countries with monoethnic populations. We aimed to investigate th...