Water-soluble compounds from Lignosus rhinocerus TM02 ® (xLr™) modulate ACE2 activity and inhibit its interaction with SARS-CoV-2 spike-protein

• Main Authors: Goh, Neng-Yao, Yap, Yeannie Hui-Yeng, Ng, Chyan Leong, Kong, Boon Hong, Ng, Szu-Ting, Tan, Chon-Seng, Razif, Muhammad Fazril Mohamad, Fung, Shin Yee
• Format: Article
• Published: Elsevier 2024
• Subjects: R Medicine
• Online Access: http://eprints.um.edu.my/45173/; https://doi.org/10.1016/j.fbio.2024.104232
• Institution: Universiti Malaya

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a coronavirus that causes COVID-19 by attaching its spike protein (S-protein) to the ACE2 receptor on host cells. This interaction is critical for viral entry and infection. Water-soluble compounds found in the medicinal mushroom Lignos...