Biocatalytic Generation of o-Quinone Imines in the Synthesis of 1,4-Benzoxazines and Its Comparative Green Chemistry Metrics

• Main Authors: Tehami, Maryam, Imam, Hasan Tanvir, Abdullah, Iskandar, Hosford, Joseph, Wong, Xiao Juie, Rahman, Noorsaadah Abd, Wong, Lu Shin
• Format: Article
• Published: American Chemical Society 2024
• Subjects: Q Science (General); QD Chemistry
• Online Access: http://eprints.um.edu.my/45667/; https://doi.org/10.1021/acssuschemeng.3c06758
• Institution: Universiti Malaya

1,4-Benzoxazines are important motifs in many pharmaceuticals and can be formed by a reaction sequence involving the oxidation of o-aminophenols to their corresponding quinone imine followed by an in situ inverse electron demand Diels-Alder (IEDDA) cycloaddition with a suitable dienophile. Reported...