Platanosides from Platanus x acerifolia: New molecules, SAR, and target validation of a strong lead for drug-resistant bacterial infections and the associated sepsis

• Main Authors: Wu, Xi-Ying, Zhao, Ze-Yu, Osman, Ezzat E. A., Wang, Xiao-Juan, Choo, Yeun-Mun, Benjamin, Menny M., Xiong, Juan, Hamann, Mark T., Luo, Cheng, Hu, Jin-Feng
• Format: Article
• Published: Elsevier 2024
• Subjects: QD Chemistry; R Medicine (General); RM Therapeutics. Pharmacology; RS Pharmacy and materia medica
• Online Access: http://eprints.um.edu.my/45804/; https://doi.org/10.1016/j.bioorg.2024.107103
• Institution: Universiti Malaya

Three undescribed (1-3) and nine known (4-12) platanosides were isolated and characterized from a bioactive extract of the May leaves of Platanus x acerifolia that initially showed inhibition against Staphylococcus aureus. Targeted compound mining was guided by an LC-MS/MS-based molecular ion networ...