ATG16L1 rs2241880/T300A increases susceptibility to perianal Crohn's disease: An updated meta-analysis on inflammatory bowel disease risk and clinical outcomes

• Main Authors: Simovic, Isidora, Hilmi, Ida, Ng, Ruey Terng, Chew, Kee Seang, Wong, Shin Yee, Lee, Way Seah, Riordan, Stephen, Castano-Rodriguez, Natalia
• Format: Article
• Published: John Wiley & Sons Ltd 2024
• Subjects: R Medicine (General); RJ Pediatrics
• Online Access: http://eprints.um.edu.my/46002/
• Institution: Universiti Malaya

BackgroundATG16L1 plays a fundamental role in the degradative intracellular pathway known as autophagy, being a mediator of inflammation and microbial homeostasis. The variant rs2241880 can diminish these capabilities, potentially contributing to inflammatory bowel disease (IBD) pathogenesis.Objecti...