Calcitriol (1,25-dihydroxycholecalciferol) selectively inhibits proliferation of freshly isolated tumor-derived endothelial cells and induces apoptosis

• Main Authors: Flynn, G., Chung, I., Yu, W.D., Romano, M., Modzelewski, R.A., Johnson, C.S., Trump, D.L.
• Format: Article
• Language: English
• Published: 2006
• Subjects: R Medicine
• Online Access: http://eprints.um.edu.my/5070/1/Flynn-2006-Calcitriol_%281%2C25-dih.pdf; http://eprints.um.edu.my/5070/
• Institution: Universiti Malaya

Calcitriol (1,25-dihydroxycholecalciferol) has antiproliferative and/or proapoptotic effects on many cell types and the glucocorticoid dexamethasone enhances these effects. We have shown that calcitriol modulates several key signaling proteins involved in differentiation, proliferation and apoptosis...